Which of the following is a non-CRAB feature in plasma cell disorders?

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Multiple Choice

Which of the following is a non-CRAB feature in plasma cell disorders?

Explanation:
End-organ damage signals the CRAB features in plasma cell disorders. Hypercalcemia, renal impairment, anemia, and bone lesions are manifestations of how malignant plasma cells harm the body. The M-spike is a laboratory finding—a monoclonal immunoglobulin produced by abnormal plasma cells seen on electrophoresis. It indicates a plasma cell clone but does not by itself reflect organ damage. Therefore, the M-spike is a non-CRAB feature, distinguishing a laboratory marker from the actual end-organ effects of the disease. In many cases, you can have an M-spike without CRAB features (as in MGUS), whereas CRAB features point to active, end-organ–damaging disease.

End-organ damage signals the CRAB features in plasma cell disorders. Hypercalcemia, renal impairment, anemia, and bone lesions are manifestations of how malignant plasma cells harm the body. The M-spike is a laboratory finding—a monoclonal immunoglobulin produced by abnormal plasma cells seen on electrophoresis. It indicates a plasma cell clone but does not by itself reflect organ damage. Therefore, the M-spike is a non-CRAB feature, distinguishing a laboratory marker from the actual end-organ effects of the disease. In many cases, you can have an M-spike without CRAB features (as in MGUS), whereas CRAB features point to active, end-organ–damaging disease.

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