Which immunophenotype is characteristic of CLL?

Prepare for the Hematologic, Immunologic, and Neoplastic Disorders Test. Study with flashcards and multiple-choice questions, each with explanations and hints. Get ready for your exam!

Multiple Choice

Which immunophenotype is characteristic of CLL?

Explanation:
The hallmark for CLL is a B-cell immunophenotype that coexpresses CD5 and CD23 along with CD19 and CD20 (CD20 often dim). CD5 is normally a T-cell marker but is aberrantly present on CLL B cells, and CD23 positivity helps distinguish CLL from other CD5+ B-cell malignancies like mantle cell lymphoma, which is CD23 negative. CD19 confirms B-lineage, and CD20 is present but typically dim in CLL. Other immunophenotypes point to different lineages or diseases: CD3 and CD56 indicate T‑cell or NK-lineage involvement; CD10 with CD19 and CD20 suggests precursor or germinal center B-cell processes (not classic CLL); CD14 and CD33 reflect myeloid lineage involvement.

The hallmark for CLL is a B-cell immunophenotype that coexpresses CD5 and CD23 along with CD19 and CD20 (CD20 often dim). CD5 is normally a T-cell marker but is aberrantly present on CLL B cells, and CD23 positivity helps distinguish CLL from other CD5+ B-cell malignancies like mantle cell lymphoma, which is CD23 negative. CD19 confirms B-lineage, and CD20 is present but typically dim in CLL.

Other immunophenotypes point to different lineages or diseases: CD3 and CD56 indicate T‑cell or NK-lineage involvement; CD10 with CD19 and CD20 suggests precursor or germinal center B-cell processes (not classic CLL); CD14 and CD33 reflect myeloid lineage involvement.

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