What cells are pathognomonic on biopsy for Hodgkin lymphoma?

Prepare for the Hematologic, Immunologic, and Neoplastic Disorders Test. Study with flashcards and multiple-choice questions, each with explanations and hints. Get ready for your exam!

Multiple Choice

What cells are pathognomonic on biopsy for Hodgkin lymphoma?

Explanation:
Reed-Sternberg cells are the hallmark histologic feature of classic Hodgkin lymphoma. These are large, often binucleated cells with prominent nucleoli that give the characteristic “owl’s eye” appearance. Immunophenotypically, they express CD15 and CD30, while usually lacking CD45. The combination of these distinctive cells with that immunophenotype on lymph node biopsy essentially confirms classical Hodgkin lymphoma. Other cell types listed point to different diseases—Auer rods in AML, smudge cells in CLL, and lymphoblasts in ALL—so they do not define Hodgkin lymphoma.

Reed-Sternberg cells are the hallmark histologic feature of classic Hodgkin lymphoma. These are large, often binucleated cells with prominent nucleoli that give the characteristic “owl’s eye” appearance. Immunophenotypically, they express CD15 and CD30, while usually lacking CD45. The combination of these distinctive cells with that immunophenotype on lymph node biopsy essentially confirms classical Hodgkin lymphoma. Other cell types listed point to different diseases—Auer rods in AML, smudge cells in CLL, and lymphoblasts in ALL—so they do not define Hodgkin lymphoma.

More practice questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy