Reed-Sternberg cells on biopsy are characteristic of which lymphoma?

Prepare for the Hematologic, Immunologic, and Neoplastic Disorders Test. Study with flashcards and multiple-choice questions, each with explanations and hints. Get ready for your exam!

Multiple Choice

Reed-Sternberg cells on biopsy are characteristic of which lymphoma?

Explanation:
Reed-Sternberg cells are the defining feature of Hodgkin lymphoma. These are large, binucleated B cells with prominent nucleoli that give an owl’s-eye appearance on biopsy, typically seen within a background of mixed inflammatory cells. Their presence, often with CD15 and CD30 positivity and usually CD45 negativity, distinguishes Hodgkin lymphoma from other lymphoid proliferations. By comparison, Auer rods point to acute myeloid leukemia, Smudge cells to chronic lymphocytic leukemia, and Birbeck granules to Langerhans cell histiocytosis.

Reed-Sternberg cells are the defining feature of Hodgkin lymphoma. These are large, binucleated B cells with prominent nucleoli that give an owl’s-eye appearance on biopsy, typically seen within a background of mixed inflammatory cells. Their presence, often with CD15 and CD30 positivity and usually CD45 negativity, distinguishes Hodgkin lymphoma from other lymphoid proliferations. By comparison, Auer rods point to acute myeloid leukemia, Smudge cells to chronic lymphocytic leukemia, and Birbeck granules to Langerhans cell histiocytosis.

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