In addition to bone pain, which symptom is commonly reported with Ewing sarcoma?

• A. Nausea
• B. Fever
• C. Weight loss
• D. Night sweats

Answer: (B)

Fever is a common systemic symptom that often accompanies Ewing sarcoma in addition to the localized bone pain. The tumor can provoke an inflammatory response, releasing cytokines that cause fever and a sense of malaise. This makes fever a characteristic accompanying sign, helping distinguish the broader clinical picture from bone-only symptoms. Nausea, weight loss, and night sweats can occur with many illnesses and cancers, but they are not as consistently linked to Ewing sarcoma as fever is. Keep in mind that, especially in children and adolescents, Ewing sarcoma may mimic infections like osteomyelitis when fever is present, which is why a thorough workup with imaging and biopsy is important for accurate diagnosis.